Kill Hillock at the end of the beach. First quest in the game.

Find the Medicine Chest on The Tidal Island (off The Coast) and kill Hailrake. Return to Nessa.

Find the 3 Glyphs in the Rhoa nests of The Mud Flats and use them to open The Submerged Passage.

Clear all monsters in The Fetid Pool (side area off The Mud Flats). Return to Tarkleigh.

Kill The Deep Dweller in The Flooded Depths (off The Submerged Passage). Return to Tarkleigh.

Kill Brutus in The Upper Prison. Talk to Tarkleigh and Nessa for two gem rewards.

Find the Allflame in The Ship Graveyard Cave, then kill Captain Fairgraves in The Ship Graveyard. Return to Bestel.

Kill Merveil in The Cavern of Anger. Main Act 1 boss — opens the path to Act 2.

Kill Captain Arteri in The Western Forest for the Thaumetic Emblem. Use it on the seal in Act 1's Prisoner's Gate, then talk to Bestel.

Kill Fidelitas in The Chamber of Sins Level 2 and take the Baleful Gem. Return to Greust.

Find the Golden Hand in The Crypt Level 2 (via The Fellshrine Ruins). Return to Yeena.

Kill The Great White Beast in The Den (off Old Fields). Return to Yeena.

Kill The Weaver in The Weaver's Chambers and take Maligaro's Spike. Return to Silk.

Kill or help Kraityn (The Broken Bridge), Alira (The Western Forest) and Oak (The Wetlands). Killing all three = 1 passive point from Eramir. Eramir then gives you The Apex.

Use the Baleful Gem and Maligaro's Spike to poison the ancient tree blocking The Vaal Ruins in The Wetlands.

Use The Apex to enter The Ancient Pyramid. Kill the Vaal Oversoul. Opens Act 3.

Find Tolman in The Crematorium. Kill Piety. Bring Tolman's Bracelet to Clarissa. Get Sewer Keys.

Find 3 platinum busts in The Sewers. Return to Hargan in Sarn Encampment.

Find the Ribbon Spool in The Battlefront. Give it to Lady Dialla in The Solaris Temple.

Find the Thaumetic Sulphite in The Docks. Lady Dialla gives you Infernal Talc to burn the blockages in The Sewers.

Bring Chitus' Plum and the Decanter Spiritus (The Docks) to Captain Fairgraves' ghost.

Kill General Gravicius in The Ebony Barracks.

Find the tomb of the Gemling Queen, Lady Dialla, in The Solaris Temple Level 2.

Kill Piety in The Lunaris Temple Level 2. Return to Grigor.

Find 4 Golden Pages in The Archives (via The Library). Return to Siosa.

Climb the Sceptre of God. Kill Dominus on the roof. Opens Act 4.

Kill Voll in The Dried Lake for Deshret's Banner. Use it in Highgate to break the seal to The Mines. Return to Oyun.

Free Deshret's spirit in The Mines Level 2. Return to Tasuni in Highgate.

Kill King Kaom in Kaom's Stronghold. Collect the Eye of Fury.

Kill Daresso in The Grand Arena. Collect the Eye of Desire.

Collect Malachai's three organs from Doedre, Maligaro and Shavronne in The Harvest. Deliver them to Piety.

Kill Malachai in The Black Core. Opens Act 5.

Climb The Ascent to the portal to Oriath. Escape The Slave Pens and kill Overseer Krow. Talk to Lani.

Kill Justicar Casticus in The Control Blocks. Return to Lani.

Find the Miasmeter in The Control Blocks. Return to Vilenta.

Kill High Templar Avarius in The Chamber of Innocence.

Kill Utula in The Ruined Square. Return to Bannon.

Find Kitava's three Torments in The Reliquary (off The Ruined Square). Return to Lani.

Kill Kitava on The Cathedral Rooftop. Ends Part 1. Permanent −30% to all elemental resistances.

Clear The Twilight Strand for Lilly Roth. Unlocks her gem shop (most gems for any class).

Find Bestel's Manuscript (Act 6). Return to Bestel.

Kill Shavronne and Brutus in The Prison so Sin can harvest her soul. Talk to Tarkleigh.

Kill Tukohama in The Karui Fortress. Talk to Tarkleigh.

Kill Ryslatha in The Spawning Ground (off The Wetlands). Return to Tarkleigh.

Kill Abberath in The Prisoner's Gate. Talk to Bestel.

Light the Beacon. Kill The Brine King. Ends Act 6.

Find Weylam's Silver Locket near The Broken Bridge. Return to Weylam.

Take Maligaro's Map from The Crypt and place it on the Reverie Device in The Chamber of Sins. Kill Maligaro. Talk to Helena.

Take the Black Venom from Maligaro's spider in Maligaro's Sanctum. Give it to Silk in The Chamber of Sins.

Kill Greust, possessed by Ralakesh, in The Ashen Fields. Return to Eramir.

Find Kishara's Star in The Causeway. Return to Weylam Roth.

Find Greust's Necklace in The Causeway and place it on his grave in The Ashen Fields. Talk to Helena.

Kill Gruthkul, Mother of Despair, in The Dread Thicket. Return to Eramir.

Collect 7 Fireflies in The Dread Thicket. Yeena burns open the entrance to The Temple of Decay.

Kill Arakaali in The Temple of Decay Level 2. Opens Act 8.

Find the Ankh of Eternity in The Quay, bring it to Clarissa, then kill undead Tolman. Talk to Clarissa.

Kill Doedre Darktongue in The Toxic Conduits so Sin can harvest her soul. Return to Hargan.

Find the Wings of Vastiri in The Bath House. Return to Hargan.

Kill Yugul, Reflection of Terror, in The High Gardens (off The Bath House). Return to Hargan.

Kill the Gemling Legionnaires at The Grain Gate. Return to Maramoa.

Kill Dusk in The Lunaris Concourse. Needed before the final Act 8 boss.

Kill Dawn in The Solaris Concourse, then defeat Solaris and Lunaris at The Harbour Bridge. Opens Act 9.

Find the Storm Blade in The Vastiri Desert. Talk to Petarus and Vanja in Highgate.

Find the Calendar of Fortune in the Vastiri Desert. Return to Irasha in Highgate.

Kill Shakari in The Oasis (off The Vastiri Desert). Return to Irasha.

Kill Kira and Garukhan in The Quarry. Give the Sekhema Feather to Tasuni or Irasha.

Bring Basilisk Acid (The Boiling Lake) and Trarthan Powder (The Refinery) to Sin. Kill the Depraved Trinity in The Rotting Core. Opens Act 10.

Save Bannon on The Cathedral Rooftop.

Find the Elixir of Allure in The Ossuary. Return to Lani in Oriath Docks.

Kill Vilenta in The Control Blocks (Act 10, off The Ravaged Square). Return to Lani.

Find the Map to Tsoatha in The Reliquary (Act 10). Return to Weylam Roth.

Kill Avarius in The Desecrated Chambers to free Innocence.

Kill Kitava in The Feeding Trough. Final campaign boss. Talk to Lani. Permanent −30% to all elemental resistances (−60% total).